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1999, plasma half-life approximately two hours after intravenous administration in healthy male volunteers) measured growth hormone release as the sole pharmacodynamic readout and did not measure plasma cortisol, ACTH, or prolactin in humans [4]

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Growth hormone and other peptides in a bacteriostatic environment can maintain their stability and resist degradation for much longer

In the Phase 2 obesity trial published in the New England Journal of Medicine, the highest arm reached 24.2 percent average body weight loss at 48 weeks, and the curve had not flattened by the end