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It has been one of the most extensively studied peptides in preclinical gastroenterology and tissue biology research, with over 100 published animal studies examining its effects across multiple organ systems

TABLE 1 Demographics and clinical characteristics of sample population

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More importantly, the synthesis of SAM, which requires the folate cycle, is crucial in neuropsychiatry for its role as a therapeutic agent in the treatment of depression, and as an antidepressant in Parkinsons disease (30, 65, 67)

Sci Rep 10 , 5686 (2020)

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