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Rheumatology (Oxford) 2012;51 Suppl 5:v311
The discrepancies of GLP-1 in these studies definitely depend on the model (in vivo/in vitro), species, and the duration of GLP-1 (short/sustained half life)
Sticking to one serving per day is also an option
For people with certain conditions like pancreatic insufficiency, lactose intolerance, or specific enzyme deficiencies, supplemental enzymes have shown clear benefits
Analysis of the L-Glu-bound crystal structure of BlGGT (PDB ID: 4OTU) suggested importance for another highly conserved residue, Asn450, located close to the binding pocket, in proper substrate orientation (Lin et al., 2016)
The best results appear around the eyes, mouth, forehead, and cheeks
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