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Mechanistically equivalent GH release with pharmacologically eliminated prolactin and cortisol co-stimulation , establishes Ipamorelin as the reference selective GHS-R1a agonist and the essential comparative control compound for all research seeking to distinguish GH-specific from co-secretion-dependent biological effects in the GH secretagogue pharmacology literature

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N Engl J Med 373:22472257 Marso SP, Daniels GH, Brown-Frandsen K, Kristensen P, Mann JF, Nauck MA, Nissen SE, Pocock S, Poulter NR, Ravn LS, Steinberg WM, Stockner M, Zinman B, Bergenstal RM, Buse JB (2016) LEADER Steering Committee

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