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72,73 The increase in intracellular cAMP after GLP-1R activation then activates a guanine nucleotide exchange factor called Epac (Exchange Protein directly Activated by cAMP), which induces PI3K activation followed by Akt phosphorylation

There are eight members (GPX1GPX8) in mammalian GPX family ( 2+ in the labile iron pool ( c , a Na + -independent cystine/glutamate reverse transporter on the cell membrane ( c belongs to the heteromeric amino acid transporter family, which consists of two components linked by disulfide: the light-chain subunit solute carrier family 7 member 11 (SLC7A11) and the heavy-chain subunit solute carrier family 3 member 2 (SLC3A2) (Sato et al., 1999)

Glucagon-like Peptide 1 Receptor Activation Inhibits Microglial Pyroptosis via Promoting Mitophagy to Alleviate Depression-like Behaviors in Diabetic Mice

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