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7 Hypoglycemia (Low blood glucose) Risk: While GLP-1 agonists have a lower risk of causing hypoglycemia compared to other diabetes medications, the risk increases significantly when they are used in combination with insulin or sulfonylureas, which actively lower blood sugar

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Those participants were then re-randomized to take either orforglipron or a placebo pill for another 52 weeks, while continuing diet and physical activity counseling

In the nucleus accumbens, GLP-1 receptor activation increases dopamine uptake by enhancing dopamine transporter activity

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