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The precursor is proteolytically cleaved at a furin site to yield a highly glycosylated extracellular -subunit and a transmembrane -subunit, which are linked together by a disulfide bridge

Studies have also indicated interactions with opioid pathways DSIP administration has been shown to modulate pain perception and has effects that can be partially blocked by opioid antagonists in some paradigms, suggesting opioidergic involvement in at least some of its actions

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ORahilly, Stephen (2021-04)

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Activation of specific heterotrimeric G proteins involves different regions of the receptors intracellular loops, primarily the third intracellular loop (8, 50, 68)