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In support of this idea, Pietschmann et al

A prespecified analysis of SELECT further suggested reductions in composite HF outcomes among participants with and without prior HF, although these findings were secondary analyses rather than HF-dedicated trial endpoints [17]

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However, the effects of rifaximin and L-carnitine on skeletal muscle atrophy, as well as the underlying mechanisms that are particularly associated with the modulation of the gut-liver-muscle axis, remain obscure

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