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Study findings The risk of new-onset DR was slightly higher among GLP-1 RA users (hazard ratio 1.07, a 0.2% absolute increase over two years), but the incidence of NAION was numerically higher but not statistically significant in this group

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The latter, in turn, promotes ovarian theca cell steroidogenesis and suppresses hepatic synthesis of sex hormone-binding globulin (SHBG), thus increasing free testosterone levels and driving HA (72)

[26] showed that liraglutide-dependent weight loss relies on its binding to GLP-1Rs located mainly in POMC/CART (cocaine- and amphetamine-regulated transcript) anorexigenic neurons in the ARC, but an indirect inhibitory effect of agouti-related peptide (AgRP) orexigenic neurons via -aminobutyric acid (GABA)-ergic signaling was also observed

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