Given the identification of 19,713 crotonylation sites across 7,637 proteins in hepatocellular carcinoma (HCC) [65], follow-up studies could further investigate butyrates regulatory effects on these proteins crotonylation modifications
46 It needs to be acknowledged, nevertheless, that with the VLED used in this study, males had a much larger energy deficit per day compared with females, which resulted in a larger overall absolute WL, and this might have contributed to the sex differences reported
Interestingly, the consumption of the reducing agent NADH was further increased by the addition of lactate (Supplementary Fig
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