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JIMD Rep 2013

Indeed, in mice fed with a high fat diet (HFD) and vaccinated against GPNMB, Suda et al

This mechanism is therapeutically beneficial for glycemic control but can decrease bioavailability of compounds requiring rapid gastric transit, particularly time-sensitive medications like oral contraceptives

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Severe dermatitis with loss of epidermal Langerhans cells in human and mouse zinc deficiency

Thus, the cyclical mechanism involving palmitoylation and depalmitoylation ensures that GSDMD-NT oligomerizes only at the correct location, which prevents premature or aberrant pore formation