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There was a significant reduction in LS-mean change from baseline in AUC Glucose0-2h at 12 weeks both in the high GLP-1 and low GLP-1 groups with a greater degree of reduction seen in the high GLP-1 group compared to the low GLP-1 group by -156.26 mmol/L.min (95% CI -272.81, -39.72 mmol/L.min)

This issue is often assessed through in silico models, where computational filters such as Lipinski's Rule of Five, Ghose, and Veber criteria are applied to predict molecular properties, including solubility, permeability, and stability

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This allows the nutrient to bypass the harsh environment of the digestive tract and be delivered directly to the cells

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