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There is some evidence of IgA and IgG antibodies against gut commensals being elevated in MS, which might reflect an aberrant immune surveillance of the gut microbiota that spills over to CNS-directed immunity [190]
They advocate for a treatment approach that is: Symptom-led : Recognising that many patients become symptomatic well before their next scheduled dose, meaning they are being under-treated
This review is reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement 2020 (Page et al., 2021)
Therefore, targeting mitochondrial mechanisms makes sense
Artif Cells Nanomed Biotechnol (2021) 49(1):8395
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