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Through their action these enzymes (and L-carnitine) are involved in energy production and metabolic homeostasis

The appetite controlling center(s) continuously receive peripheral inputs from the body that affects these neurons, and the GIT provides some of the key signals that results in hunger that tend to initiate a meal, or satiety that tend to terminate a meal, or satiation that tend to motivate the animal to not ingest a new meal for some time (the period between meals)

In laboratory settings, it is commonly studied in peptide signalling and copper-binding research applications

& Zaritsky, J

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The Role of Leptin-Melanocortin System and Human Weight Regulation: Lessons from Experiments of Nature