The pharmaceutical company highlights that both primary endpoints were to demonstrate that oral Foundayo or Zepbound continuation at either the reduced dose or MTD was superior to placebo in maintaining body weight reduction
Carnosine is found in the human body not only in relatively high millimolar concentrations in excitable tissues (skeletal muscle and brain [1]) but also in smaller amounts in other tissues (gastrointestinal tract, kidney, liver, adipose tissue and heart) [2]
In one-way sensitivity analysis, the ICER remained within 4.30 million to 6.30 million/QALY in the non-T2D cohort and 5.74 million to 8.44 million/QALY in the T2D cohort when key parameters were varied, and no plausible variation changed the direction of incremental costs and QALYs
J Biol Chem 104:415421 Damle MS, Newton LAA, Villalba MM, Leslie R, Davis J (2010) Plumbagin: a new route to the electroanalytical determination of cystine
Your prescriber will weigh efficacy, diabetes status, and personal risk factors
& Cervinkova, Z
