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This dual dependency on CYP3A4 and P-gp creates a well-defined vulnerability
Robles-AlmazanMPulido-MoranMMoreno-FernandezJRamirez-TortosaCRodriguez-GarciaCQuilesJLet al
Front Nutr 9:1015371 da Cruz TP, Wernick B, Gonalves GS, Furuya VR, Furuya WM (2024a) Impacts of -mannanase on fecal viscosity, digestible energy content, amino acid digestibility, and nutrient loss in juvenile Nile tilapia fed soybean meal-rich diets
The 4-phosphopantetheine group serves as the acyl carrier portion (ACP) of several lipid biosynthetic enzymes that includes cytosolic fatty acid synthase and the mitochondrial NDUFAB1 encoded protein (NADH:ubiquinone oxidoreductase subunit AB1) which serves as the ACP in mitochondrial fatty acid synthesis