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This phenotype was rescued by PARP1 inhibition or by supplementation with NAD+ precursors that also rescue the lifespan defect in xpa1 nematodes (Fang et al

Matsumura N, Kinoshita C, Bhadhprasit W, Nakaki T, Aoyama K (2023) A purine derivative, paraxanthine, promotes cysteine uptake for glutathione synthesis

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In contrast, IGFBP 5 induces cellular adhesion and inhibits migration of MCF7 cells via the activation of AKT in an IGF-independent manner, consistent with previous studies suggesting an apoptotic role for IGFBP 5 in BrCa [68]