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Why that matters: cortisol and GLP-1 effectiveness are inversely linked, and perimenopausal estrogen decline dysregulates the HPA axis, raising baseline cortisol and driving hormonal belly fat redistribution that keeps women stuck at a normal BMI with real metabolic dysfunction

She was asymptomatic at that time

For context on timelines with similar compounds, see our guide on semaglutide appetite suppression timelines

This is where the search for the cheapest glp1 becomes risky

Tools for tracking and optimizing your timing Optimization requires measurement

What is the difference between Semaglutide and Tirzepatide