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Jaime Almandoz, associate professor of medicine and medical director of the Wight Wellness Program at UT Southwestern Medical Center
In attempting to understand whether manipulation of NEP24.11 to prevent the degradation of GLP-1 into GLP-1(2836) would affect the clinically observed cardioprotective actions of GLP-1, we found that the in vitro cAMP response to GLP-1 was lost with addition of the NEP24.11 inhibitor sacubitril
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Phase 1 (Safety & Dosage): Tests safety, side effects, and appropriate dosage in a small group of participants (20100)
Mechanism: GLP-1s can lower blood pressure, improve cholesterol levels, and reduce inflammation in the blood vessels, all of which contribute to their cardioprotective effects
He estimated that they cost him thousands of dollars a year
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