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The study's findings suggest that hydromethylthionine has dose-dependent effects on cognitive decline and brain atrophy in mild-to-moderate AD

Concerning the structure, Nrf2 displays seven highly conserved Neh (Nrf2-ECH homology) domains, from Neh1 to Neh7 (Figure 1)

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10.1016/j.ejphar.2017.06.016 [DOI] [PubMed] [Google Scholar] 51.Jamwal S, Kumar P

doi: 10.1158/1078-0432.CCR-18-0106 79 HayashiTFujitaKMatsushitaMHayashiYUemuraMNonomuraN

Inhibition of DHODH cannot increase the sensitivity of cells to FIN56-induced ferroptosis, while the decrease in CoQ cells was more sensitive to ferroptosis than DHODH knockout cells