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FEEDBACK REGULATION OF THE HPA AXIS Glucocorticoid feedback occurs at multiple levels: at the pituitary, at the hypothalamus, and most importantly, centrally at the level of the hippocampus, which contains the highest concentration of glucocorticoid receptors in the central nervous system

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This was evident from the reversal of increased IL-6 and TNF- levels, decreased IL-10 levels, and correction of elevated sFlt-1 (Fig

doi: 10.1016/j.neuropharm.2020.108352 5

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