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Patients using oral hormonal contraceptives are advised to switch to a non-oral contraceptive method or add a barrier method of contraception for four weeks after initiation with tirzepatide and for four weeks after each dose escalation. Still, experts caution against the idea that the drugs make people more fertile

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This raises the question of whether some patients might require longer treatment to sustain weight loss

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Mechanism: These symptoms occur when blood vessels in the skin widen, allowing more blood to flow to the area