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However, defects in insulin signaling or a state of insulin resistance has been seen as an early sign of T2D manifestation, which is likely to occur simultaneous to other metabolic dysregulations, including enhanced inflammatory signaling, generation of oxidative products and initiation of endoplasmic reticulum stress pathways (Muoio and Newgard, 2008)

DXA scan The whole-body composition will be assessed by a dual-energy X-ray absorptiometry (Discovery A

You engage in intense exercise without adjusting your medication dose or food intake