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Treatment focuses on lifestyle modification, particularly weight loss of 710% of body weight, alongside managing associated conditions such as diabetes, hypertension, and high cholesterol with appropriate medications like metformin and statins

Of note, people with type 2 diabetes had a lower mean percentage weight loss at the 3-month mark compared with those without type 2 diabetes: 3.9% in those with type 2 diabetes vs 6.3% in those without type 2 diabetes

The partial appetite suppression may provide just enough behavioral nudge to reduce caloric intake sufficiently for small-scale weight management

Whether these pathways confer comparable anti-inflammatory effects within skin cells remains to be elucidated(Fig

More drugs have become available in recent years [4]

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