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Data Collection and Statistical Analysis Data were extracted from 43 relevant studies, including patient age and sex, presenting symptoms, lesion size, tumor location, and surgical management and outcomes, including metastasis, long-term recurrence, and survival

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Many patients begin with a three month program to allow enough time to evaluate results and optimize dosing with physician guidance

(10) Studies have documented that IGF-1 signaling promotes fibroblast proliferation, collagen synthesis, and angiogenesisall critical components of wound healing