Does not raise stress hormones Cortisol, ACTH, and prolactin stay flat at standard doses
Patients should disclose a history of pancreatitis, gallbladder disease, severe gastrointestinal disease, kidney disease or other dehydration risks, use of diabetes medications such as insulin or sulfonylureas, pregnancy or plans for pregnancy, any personal or family history of medullary thyroid carcinoma or MEN2, and a history of diabetic retinopathy
4 A history of gallbladder disease A 2022 systematic review of 76 randomised trials found that GLP-1 medications are associated with a relative risk of around 37% for gallbladder or biliary disease, with a higher relative risk in weight-loss trials than in diabetes trials
Furthermore, neurodegenerative diseases develop from a multitude of pathological hallmarks, hence, the therapeutic targeting of only one of them might not have a significant effect on the course of a heterogenous disorder
The Mayo Clinic, a nonprofit medical center and research group, describes obesity as a medical problem that involves having too much body fat and increases the risk of other health diseases and health problems, such as diabetes and heart disease
G., Bardelli, D., Chiu, M
