Everybody is different, and weight loss takes time and patience
We can see that by looking at the returns if we had equally weighted every single short we ever put on in the basket and then comparing that to the performance of the benchmark: Our shorts down more than 31% while the S&P500 is up more than 20%
GLP-1 receptor agonists and GIP/GLP-1 dual agonists carry a deep trial record: STEP studied semaglutide for weight management (NEJM 2021), SURMOUNT studied tirzepatide for weight management (NEJM 2022), and SURMOUNT-OSA studied tirzepatide for obstructive sleep apnea (NEJM 2024)
Effect of laparoscopic sleeve gastrectomy vs Roux-en-Y gastric bypass on weight loss, comorbidities, and reflux at 10 years in adult patients with obesity: the SLEEVEPASS randomized clinical trial
Pyocyanin induces the secretion of IL-23 to promote the differentiation and activation of Th17 cells, a subset of T-helper cells that play a key role in sustaining chronic inflammatory states (93, 159)
But what are they really