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Stem-cell derived BBB models are the newest cell type model and have significantly higher expression of tight junction protein and transporters as well as TEER compared to hCMEC/D3 cells [118, 119]

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doi: 10.1016/j.biopha.2020.110195 303 ZhangR.SunC.ChenX.HanY.ZangW.JiangC.et al

Thats because if you use Phase I supportive supplements as a standalone, they will begin to convert the toxins into intermediate byproducts, but many of these byproducts are more harmful than the original toxins and may not clear from the body if you dont have enough Phase II-supporting amino acids