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Among the emerging peptides gaining attention is Dihexa , sometimes referred to simply as the cognitive enhancer due to anecdotal reports of its potential to improve learning, memory, and neuroprotection

Additionally, the expression of nuclear respiratory factor 1 and estrogen-related receptor (NRF-1 and ERR), which are downstream of PGC, is also inhibited, further exacerbating mitochondrial dysfunction and impeding gluconeogenesis

Front Neurosci 2015;9:387.ArticlePubMedPMC 61