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GLP-1 is a hormone released in the intestines in response to food intake, and it plays a pivotal role in regulating blood sugar levels, insulin secretion, and satiety

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Int J Epidemiol (2017) 46(3):798f

Constipation sometimes continues beyond the first week and often resolves with hydration, fiber, or stool softeners within the first month

The 8-week induction period demonstrated statistically significant dose-dependent reductions in total MS compared to placebo, with the primary endpoint showing placebo-adjusted mean reductions of -2.0, -3.9, and -4.6 points for the 20mg, 70mg, and 200mg doses respectively (all p 1.3 million-fold selectivity for TYK2 over JAK1

Study limitations This meta-analysis has several limitations that should be considered when interpreting the findings