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Cellular and molecular mechanisms of the bloodbrain barrier dysfunction in neurodegenerative diseases

Without adequate glutathione, detox slows and toxins linger longer than they should (NIH)

No specific antidote is available Supportive care remains the mainstay of management Strict adherence to recommended dosing guidelines is essential to minimize the risk of toxicity and unintended physiological disruption

Most research focuses on metabolic disorders and cardiovascular diseases (Barreca et al

Animal studies have revealed that mild to moderate acoustic overexposure, even when causing only a temporary threshold shift (TTS), can immediately and permanently induce cochlear synaptopathycharacterized by the loss of synaptic connections between cochlear hair cells and auditory nerve fibers, without any loss of the hair cells themselves 16,17,18