All cellular macromolecules are susceptible to oxidative harm
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However, in tauopathies such as AD, as well as in hibernation, tau undergoes hyperphosphorylation catalyzed by various protein kinases, including but not limited to glycogen GSK3, cyclin-dependent kinase 5 (CDK5), and protein kinase A (PKA) [103,104,105], accumulating an excess of 7-10 phosphate groups [106]
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Molecular targets implicated in the antiparasitic and anti-inflammatory activity of the phytochemical curcumin in Trichomoniasis
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