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Weeks 1 to 4 (introductory phase) use a 1 to 2 percent concentration once daily in the evening, which lets the skin acclimate while the physician assesses tolerance

However, factors such as poor diet, infections and constant stress can lead to reduced levels of glutathione in the body

doi:10.1046/j.1523-1747.2000.00166.x

DSIP exhibits analgesic properties for chronic pain conditions, neuroprotective effects through antioxidant mechanisms, and geroprotective actions including 2.6-fold reduction in spontaneous tumor incidence in long-term studies

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longer duration may help sustain and amplify those effects