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Together, they create a more powerful metabolic effect than either receptor alone, which explains why tirzepatide outperforms semaglutide in clinical comparisons

They searched across multiple databases, including Cochrane Library, Web of Science, PubMed, Google Scholar, and Science Direct, to identify studies on IBS and related medications

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Pro-inflammatory cytokines increase neuronal vulnerability to apoptosis and oxidative stress by activating enzymes such as JNK, ERK, dsRNA-dependent protein kinase (PKR), and IB kinase (IKK) that reduce insulin sensitivity by serine phosphorylation of IRS1 [144, 145]