In the case of water-soluble vitamins like B12, vitamin C, folic acid, and other B vitamins, some medically reviewed literature points to early morning as the optimal time to take them as they can be taken on an empty stomach, but more peer-reviewed research is needed to confirm this claim
Mix until fully dissolved
Those who don't produce enough intrinsic factor can become deficient
Individual needs and health status ultimately determine what is best for you
With the correct dosage and length of treatment, injections may help maintain good brain function and decrease mental degeneration that can happen with aging
Perhaps most importantly, individuals with malabsorption issues may take oral supplements faithfully yet remain deficient, wasting money and time while symptoms persist