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Hyperglycemia Diabetes is associated with the accelerated disappearance of capillary endothelium [159], morphological and functional alterations of ECs [160], and the weakening of intercellular junctions [161], which ultimately leads to ECD

Dysregulation of GHIGF-1 axis can amplify the synergistic effect of GH and IGF-1 to promote uncontrolled cell proliferation, cell movement, angiogenesis, and suppress apoptosis to increase risk of neoplasia (272)

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Despite these promising results, the authors say they are a long way away from developing a drug for back pain based on this peptide, with one of many obstacles to overcome being formulation