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While these variants do not predict exact medication response, they may help provide context for why individual GLP-1 efficacy varies and can support a more personalized conversation with your provider about whether semaglutide or tirzepatide aligns better with your genetic predisposition profile

This story was reported from Orlando.

Taking a GLP-1 can be a big adjustment for your body, so its important to leave some time and space for that, Adair says

Our functional medicine team can help you look into anything that may be hindering your bodys own production of GLP-1 or causing GLP-1 resistance, and other factors that may be keeping you from feeling your best

Key points Obesity is a risk factor for developing osteoarthritis (OA), gout, rheumatoid arthritis (RA), psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA), and is associated with higher disease activity and/or severity, and worse response to common treatments

"Weight loss itself may increase a sense of autonomy or confidence, potentially empowering individuals to leave unhealthy relationships," Svensson told the outlet