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GLP-1R also functions as a pleiotropic GPCR that can activate distinct signaling cascades depending on ligand bias and the local cellular environment [511]

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Plant Sci 208:93101

And so it took the pharmaceutical industry quite a while to figure out how to make GLP-1 last longer so its not broken down, how to give small amounts to start off with, how to slowly build up the dose, et cetera

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