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Systematic review of 4 studies (3 RCTs + 1 single-arm trial)

We discuss how copper also plays a key role in proteostasis and interacts either directly or indirectly with many of the key aggregate-prone proteins implicated in ALS, such as TDP-43, C9ORF72, SOD1 and FUS as well as the effect of their aggregation on copper homeostasis

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The tradeoff is attribution complexity: more components means more variables to interpret

Mdicament rvis par Vanessa Atan, Infirmire Autorise, BSc, BA

Ex vivo studies reveal that zinc supplementation can decrease IL-1 output following LPS stimulation [572, 573]