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Peer review Peer review information Nature Communications thanks Paul Yen and the other, anonymous, reviewers for their contribution to the peer review of this work

[3] It was discovered by Chugai Pharmaceutical Co., then was licensed to Lilly in 2018

10.3389/FMED.2022.951889/FULL 71 HindW

if needed, gently press site with cotton swab (do not rub) [19]

Both MT-2 and leptin are thought to cause an increase in TRH expression in the paraventricular nucleus of the hypothalamus, a region of the brain associated with satiety and food intake, but only MT-2 crosses into the central nervous system in concentrations high enough to have an effect on TRH expression

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