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The FDA added a black box warning to metoclopramide in 2009 because chronic use exceeding 12 weeks is associated with tardive dyskinesia, a potentially irreversible movement disorder

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Constipation or Diarrhea: Changes in digestion speed can affect bowel habits

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Skin brightening involves improving the skins radiance and evenness by reducing dullness, discolouration and dark spots

NICE recommends continuing treatment only if HbA1c reduces by 11 mmol/mol (1%) at 6 months, with regular monitoring for adverse effects including pancreatitis