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In these cases, provider evaluation must address whether baseline thyroid function is stable, TSH is well-controlled, and whether introducing a GLP-1 agent poses any incremental autoimmune risk for that individual
Melson E, Ashraf U, Papamargaritis D, Davies MJ
Image source: GLP-1s and Food Noise One of the interesting impacts of the GLP1 medications is the reduction of what is called food noise, also known as food-related intrusive thoughts or food preoccupation (Mozafariun 2025)
Tirzepatide and GIP treatment lead to significantly lower interleukin-1 beta (IL1B) levels and Tirzepatide further lowered interleukin-6 (IL-6) and monocyte-chemoattractant protein-1 (MCP-1) levels, highlighting distinct tissue-specific regulatory roles in pancreatic adipose tissue metabolism and inflammation [32]
BMI 25.0 to 26.9 (overweight, below threshold)
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