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Cancer cells in tumors with IDH1 or IDH2 mutations show oncogenic activity by converting glutamine-derived -KG to 2-hydroxyglutarate (2-HG), which competitively inhibits -KG-dependent histone and DNA modification enzymes 27

The amylin-based mechanism may contribute to this selectivity

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When done under professional care, this therapy is both safe and effective, especially with the right frequency and aftercare

ALA preserve the enzyme activities of pyruvate dehydrogenase, and -ketoglutarate dehydrogenase through binding with amide linkage at lysine amino acid sites