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Melatonin is a neurohormone produced by the pineal gland that regulates sleep-wake cycles by binding to melatonin receptors (MT1 and MT2) in the brain and peripheral tissues

the data in these reports are insufficient to establish or exclude a causal relationship between MTC and GLP-1 receptor agonist use in humans

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Liu et al., 2014

In pancreatic cells, GLP-1r internalizes following stimulation with GLP-1 or various agonists, whereby the receptor is ultimately recycled to the cell surface(Roed et al., 2014)