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It is a nutrient strategy developed to support metallothionein and copper-zinc regulation

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As the disorder progresses, the feeling of tingling or numbness may become constant and patients may complain of burning pain

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However, there are some degenerative lesions, such as hydropic degeneration and cystic degeneration, that are more clearly established in traditional pathology literature

Individuals might not notice immediate symptoms, but as the deficiency progresses, it can manifest in ways that affect daily life and long-term health