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Very few studies have shown an uptake of supplemental carnitine into muscle, but the limited evidence suggests a large dose of carbohydrate (80g with each dose) is required over at least 12 weeks in order to achieve this

The patients I see with the most pronounced symptoms tend to share a few things: Rapid weight loss (more than 15 to 20 percent of body weight in under a year) Limited resistance training during their weight loss period A history of diabetes , which already puts the feet at risk Older age , because fat pad atrophy naturally happens with aging and the GLP 1 effect compounds it High mileage feet , meaning patients who are very active or stand all day for work If you have diabetes and you're on a GLP 1 drug, this is especially important to track