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The antiplasmodial activity by piperazine alkaloids derivatives from Rauvolfia mannii Stapf stembark extract against chloroquine-resistant Plasmodium falciparum has been reported, with an IC 50 value of 4.03 g/ml

Approximately 25% of gallstone patients develop biliary colic or more severe complications [2], contributing to a growing economic burden year by year [3]

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Excessive intensity of these causes molecular damage and eventually triggers PCD events

however, 19 were randomized and 3 discontinued, which lowered power for the primary endpoint and may increase the chance of a type II error

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