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Its anti-inflammatory effects are mediated by its ability to suppress the expression and release of pro-inflammatory cytokines, such as Interleukin-6 (IL-6) and Tumor Necrosis Factor-alpha (TNF-), in various cell culture models

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It's possible that lower doses of each medication might be sufficient when used together, potentially mitigating some of the side effects while maintaining efficacy

These mixed responses cannot be generalized, but the fact that a subset experience real improvement makes this an important signal to investigate

When numerous melittin particles enter the cell membrane, they degrade the phospholipids, resulting in cellular fragmentation