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A Three-Compartment Model Illustrates Unbound Drug Distribution Equilibrium Between Plasma, Brain (ISF and ICF), and CSF [1] How Do Substances Cross the Blood-Brain Barrier
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injections of 100 nmol kg 1 MK-801 ( n = 9 mice and 4 cages), 100 nmol kg 1 GLP-1 ( n = 10 mice and 4 cages), 100 nmol kg 1 GLP-1MK-801 ( n = 10 mice and 4 cages), or vehicle (isotonic saline, n = 10 mice and 4 cages) for 14 days
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