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Moreover, HFD-induced macrophage activation and proinflammatory cytokine expression were significantly reduced in both the adipose tissue and hypothalamus of Grn -MKO mice, while HFD-induced impairments in leptin and insulin signaling showed improvement

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Review article: current and future treatment approaches for IBS with diarrhoea (IBS-D) and IBS mixed pattern (IBS-M)

Jallouk, A.P., Moley, K.H., Omurtag, K., Hu, G., Lanza, G.M., Wickline, S.A